Biomedical research is becoming more data-intensive as researchers are generating and using increasingly large, complex, and diverse data sets. This era of “Big Data” taxes the ability of biomedical researchers to locate, analyze, and interact with these data (and more generally all biomedical data) and associated software due to the lack of tools, accessibility, and training. In response to these new challenges in biomedical research, NIH has developed the Big Data to Knowledge (BD2K) Initiative. Under this FOA, BD2K Centers of Excellence are sought to conduct research to advance the science and utility of Big Data in the context of biomedical and behavioral research, and to create innovative new approaches, methods, software, tools, and related resources. The Centers will advance the ability of the biomedical research enterprise to use Big Data by producing tools and resources from early-stage to mature development that will be broadly useful to the research community. Read the full grant description here.